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Prevent Sedimentation

Determine suitable vessel equipment and operating conditions based on CFD

Many processes like crystallization, vial filling or emulsification require a homogeneous dispersion of the particles. There are a number of parameters involved that determine the homogeneity, like reactor characteristics, solids loading, particle properties and more. Sedimentation needs to be avoided to maximize the yield and to obtain constant quality throuout the entire bulk. This case study shows how this can be addresses using CFD.

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Powder Dissolution

Derive powder dissolution conditions to prevent lump formation based on CFD

For some powder dissolution processes where matching the specific dissolution kinetics of the powder is critical to the drug product quality, it is essential to derive suitable process conditions. The dissolution conditions at lab scale can differ significantly from those at industrial scale. With CFD these conditions can be modelled with sufficiently high resolution in space and time, to ensure sufficient dissolution also at industrial scale.

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Robust Crystallization

Determine the ideal antisolvent addition position based on CFD

The antisolvent addition position is often not considered as one of the crucial parameters for a robust crystallization. However, at lab scale, mixing times are tyically several orders of magnitude shorter than at pilot or industrial scale. Hence, when scaling up the process, adverse scale effects can be observed. This is very costly and can also lead to a delay of the launch. See how the risk of adverse scale effects due to an unfvourable antisolvent addition strategy can be decreased.

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